[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"article-85e720c4-bedd-4985-a75d-9ac7214a12ce--":3,"related-articles-undefined-undefined-bbbe2d26-551c-4817-949f-572d06875acf-true":17},{"id":4,"type":5,"title":6,"pubDate":7,"logoUrl":8,"organisationTitle":9,"thirdParty":10,"body":11,"note":12,"city":13,"website":14,"orgId":15,"description":16},"85e720c4-bedd-4985-a75d-9ac7214a12ce","PRESSRELEASE","Potential breakthrough therapy for cancer based on Pepscan’s CLIPS ...","2017-07-06T09:00:00.174+02:00","","Pepscan",false,"\u003Cp>Potential breakthrough therapy for cancer based on Pepscan’s CLIPS technology\u003C\u002Fp>\n\u003Cp>Lelystad, 6 July 2017 - Pepscan, the Dutch biotech company specialized in protein mimicry for the discovery of therapeutics peptides, announced today important progress with a drug development program based on its proprietary CLIPS technology.\u003C\u002Fp>\n\u003Cp>A team of Bicycle Therapeutics in the UK applied  Pepscan’s CLIPS technology to identify a bicyclic CLIPS peptide that selectively binds to a protein (MT1-MMP) present on tumor cells. They subsequently linked a toxin payload to the high affinity bicyclic peptide, to create a ‘Bicycle Drug Conjugate (BDC)’. The compound, codenamed BT1718, appears to penetrate tumors rapidly. Because of its peptidic nature, BT1718 can be rapidly cleared through the kidney, which minimizes toxicity relating to payload mediated gastrointestinal and liver toxicity. Bicycle Therapeutics reported superior efficacy of BT1718 to standard of care controls in multiple preclinical patient and cell-derived mouse xenograft models.\u003C\u002Fp>\n\u003Cp>In the course of 2017, BT1718 will advance to the first stage of clinical testing in human patients; Cancer Research UK, the largest cancer charitable organization in the UK, will sponsor and fund the upcoming Phase 1 study.\u003C\u002Fp>\n\u003Cp>Wim Mol, CEO of Pepscan commented: “We are very pleased with the great progress made by Bicycle Therapeutics with their CLIPS based lead program aimed at a new therapy for the treatment of cancer. It confirms the potential of bicyclic ‘2-CLIPS’ peptides as a new generation of biotherapeutics, offering antibody-like affinity and selectivity in a small, fully synthetic molecule. Pepscan is open to work with other companies interested in applying the CLIPS technology for the discovery of novel bicyclic 2-CLIPS peptides for therapeutic or diagnostic applications”.\u003C\u002Fp>\n\u003Cp>\u003Cstrong>About Pepscan\u003C\u002Fstrong>\u003C\u002Fp>\n\u003Cp>Pepscan is a privately held company based in Lelystad, The Netherlands. Pepscan is a premier provider of peptide based products and services, and also offers its profound knowledge of peptides for drug discovery collaborations. Pepscan is specialized in constrained peptides, and is the inventor of the CLIPS constraining technology. The bicyclic ‘2-CLIPS’ peptides represent a new generation of biotherapeutics, offering antibody-like affinity and selectivity in a small, fully synthetic molecule.\u003C\u002Fp>\n\u003Cp>\u003Cstrong>About CLIPS technology\u003C\u002Fstrong>\u003C\u002Fp>\n\u003Cp>CLIPS (Chemical LInkage of Peptides onto Scaffolds) is a technology to present one or more peptides in a structurally constrained configuration. These molecules behave as functional mimics of complex protein domains.  CLIPS peptides have been used in antibody and vaccine programs to create superior immunogens in the generation of antibodies against disease relevant protein targets. This is especially valuable in the case of proteins that are inaccessible as recombinant proteins, such as GPCRs and ion-channels. CLIPS technology was invented by Pepscan, which holds various patents and patent applications worldwide.\u003C\u002Fp>\n\u003Cp>\u003Cem> Source: Website Bicycle Therapeutics, accessed June 26, 2017.\u003C\u002Fem>\u003C\u002Fp>","For further information please contact Wim Mol at:\r\nPepscan\t\t\t\t\t        \r\nZuidersluisweg 2 \t\t\t\t\r\n8243 RC Lelystad\t\t\t\t\r\nThe Netherlands\r\nhttp:\u002F\u002Fwww.pepscan.com \r\nEmail: info@pepscan.com ","Lelystad","http:\u002F\u002Fwww.pepscan.com","bbbe2d26-551c-4817-949f-572d06875acf","Potential breakthrough therapy for cancer based on Pepscan’s CLIPS technology Lelystad, 6 July 2017 - Pepscan, the Dutch biotech company specialized in protein ",[18,31,40,50,57,69,82,90,99,107],{"id":19,"title":20,"pubDate":21,"logoUrl":22,"thirdParty":10,"imageUrls":23,"orgId":15,"branches":26,"description":30},"51eb793b-bd88-411f-8736-530926e0ffd6","Anthropic certificeert Salesforce Summit Partner Nextview Consulting","2026-10-02T16:18:59.088+02:00","https:\u002F\u002Fwww.persberichten.nl\u002Ffile\u002Flogos\u002Fbbbe2d26-551c-4817-949f-572d06875acf\u002F4dfc9345-b907-4271-be8f-83822dedd95a.jpg",[24,25,24,25],"https:\u002F\u002Flh3.googleusercontent.com\u002FTmgIMmBSlHxdkEcBQZHszd86eNgdDEWHVJ0QiqYNCwAmB9SeYRXJvR-wJzbmvdkwiK8yL_suU5fIVjTFR301c_svLgV0imOVsA","https:\u002F\u002Flh3.googleusercontent.com\u002FQQscmvwmuCbZjjIAe_67c5NDgKbA9CFT74ElteTTjBFaqSRz6J1GGUrRKnaFsB2pZDi2QSV1sDlUUQ8Sz9_N6S4iL9Y-egQ",[27],{"id":28,"title":29},"12109","Arbeidsmarkt en ondernemen","Nextview Consulting, gesteund door Salesforce Ventures, wordt Anthropic Select Partner: de status die Anthropic voorbehoudt aan bedrijven met gecertificeerde ar",{"id":32,"title":33,"pubDate":34,"logoUrl":8,"thirdParty":10,"orgId":15,"branches":35,"description":39},"50141bc1-375f-43c0-9830-d30955cfbcf5","De Zwanenhof stapt naar de rechter: gemeente Borne hield miljoenen over aan noodopvang ","2026-10-02T15:02:08.242+02:00",[36],{"id":37,"title":38},"32100","Recht","Gemeente komt volgens De Zwanenhof ondertekende afspraak niet na Landgoed De Zwanenhof in Zenderen, waar sinds maart 2022 ruim honderdOekraïense ontheemden word",{"id":41,"title":42,"pubDate":43,"logoUrl":44,"thirdParty":10,"orgId":15,"branches":45,"description":49},"2dcf7fb0-7ff2-4d8f-9526-2c625fb3b087","Landelijke Warme Pootjes Challenge start op Dierendag","2026-10-02T08:32:00.037+02:00","https:\u002F\u002Fwww.persberichten.nl\u002Ffile\u002Flogos\u002Fbbbe2d26-551c-4817-949f-572d06875acf\u002F32456aba-5b9a-4bca-b6eb-83082e0b7ceb.jpg",[46],{"id":47,"title":48},"41000","Dieren en natuur","Gratis campagne van Stichting Bevordering Huisdierenwelzijn laat deelnemers een pootje op de kaart zetten en vraagt aandacht voor preventieve dierzorg Stichting",{"id":51,"title":52,"pubDate":53,"logoUrl":8,"thirdParty":10,"orgId":15,"branches":54,"description":56},"528c7e82-29b6-49c9-8b8b-245ff0500109","FORCYD breidt uit naar Zwitserland","2026-10-01T09:00:00.041+02:00",[55],{"id":28,"title":29},"En benoemt Bob Dillen tot partner om de Zwitserse vestiging te leiden FORCYD heeft vandaag zijn uitbreiding naar Zwitserland aangekondigd met de opening van een",{"id":58,"title":59,"pubDate":60,"logoUrl":61,"thirdParty":10,"imageUrls":62,"orgId":15,"branches":64,"description":68},"31a584bd-fc75-4247-acca-a1896d166b0c","AI tools verwijzen actief naar illegale goksites","2026-09-30T09:35:03.459+02:00","https:\u002F\u002Fwww.persberichten.nl\u002Ffile\u002Flogos\u002Fbbbe2d26-551c-4817-949f-572d06875acf\u002F6d7b1e79-3083-4c95-b8f0-e1108638a26e.jpg",[63],"https:\u002F\u002Forder.perssupport.nl\u002Ffile\u002Fpressrelease\u002Fbbbe2d26-551c-4817-949f-572d06875acf\u002F31a584bd-fc75-4247-acca-a1896d166b0c\u002FKVAOnderzoekGeneratieveAIenIllegaleOnlineKansspelen2026.pdf",[65],{"id":66,"title":67},"16100","IT, tech en social media","Generatieve AI-tools kunnen Nederlandse consumenten relatief eenvoudig blootstellen aan niet-vergund online kansspelaanbod. 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Ruim 70 kinderen uit groep 6 en 7 van basisschool De Baskuul trokken in een lang lint door het dorp",{"id":83,"title":84,"pubDate":85,"logoUrl":86,"thirdParty":10,"orgId":15,"branches":87,"description":89},"12ab3d8a-f760-4cff-be83-11a55a6bf685","50.993 handtekeningen voor de Wadden aangeboden in Leeuwarden en Den Haag","2026-09-28T15:30:35.015+02:00","https:\u002F\u002Fwww.persberichten.nl\u002Ffile\u002Flogos\u002Fbbbe2d26-551c-4817-949f-572d06875acf\u002Fdabf27ae-9c27-4f5a-9c9a-2a28dceba446.jpg",[88],{"id":79,"title":80},"Stichting Wij zijn de Wadden biedt dinsdag 29 september de petitie voor het behoud van een leefbaar, toegankelijk en toekomstbestendig Waddengebied aan. 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Ook medewerkers van gerechtsdeurwaarderskantoren krijgen ermee te make"]